Brighton defeated Manchester City 1-0, extending City's Premier League losing streak to two matches and closing the gap on the leaders to two points. The victory came after Brighton had already secured a convincing win against champions Arsenal this season, bolstering their title aspirations. Brighton's Fabian Hurzeler's team held on after an early goal by Yasin Ayari, despite City's persistent pressure later in the game. Conversely, Manchester United suffered another damaging defeat, their longest winless run in 38 years, against Chelsea with a 2-0 loss. Michael Carrick's team missed numerous first-half chances and then collapsed in the second half, leading to a quickfire pair of yellow cards for Lisandro Martinez, one of which resulted in a penalty that Cole Palmer converted. Carrick acknowledged the team's poor second half and expressed his expectation to manage for the upcoming Champions League match against Roma. In other matches, Bournemouth defeated Leeds 2-0 with goals from Evanilson and Amine Adli, while Sunderland remained at the bottom of the table after losing 3-1 to Coventry. Nottingham Forest's victory against Brentford was the only other result outside of these main events.

Nikola Milenkovic's own goal and Igor Thiago's strike propelled Brentford to sixth place. Hull and Ipswich drew 2-2, wrapping up the round of matches with another notable result.